abstract：OBJECTIVE:Failure to detect clinical deterioration in the hospital is common and associated with poor patient outcomes and increased healthcare costs. Our objective was to evaluate the feasibility and accuracy of real-time risk stratification using the electronic Cardiac Arrest Risk Triage score, an electronic health r...

journal_title：Critical care medicine

authors： Kang MA,Churpek MM,Zadravecz FJ,Adhikari R,Twu NM,Edelson DP

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:Hepatic ischemia-reperfusion is a major clinical problem with limited treatment options. The pathophysiology of hepatic ischemia-reperfusion is characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 is an energy-sensing enzyme known to modulate mitochondrial biogenesis. We hypothe...

journal_title：Critical care medicine

authors： Khader A,Yang WL,Godwin A,Prince JM,Nicastro JM,Coppa GF,Wang P

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Inotropic and vasopressor drugs are routinely used in critically ill patients to maintain adequate blood pressure and cardiac output in patients with cardiogenic shock although potentially at the expense of increasing myocardial oxygen demand. Pacing optimization has been demonstrated as effective in reducing...

journal_title：Critical care medicine

authors： Tavazzi G,Kontogeorgis A,Bergsland NP,Price S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To assess the reversibility of acute kidney injury-induced neutrophil dysfunction and to identify involved mechanisms. DESIGN:Controlled laboratory experiment and prospective observational clinical study. SETTING:University laboratory and hospital. SUBJECTS:C57BL/6 wild-type mice. PATIENTS:Patients with ...

journal_title：Critical care medicine

authors： Singbartl K,Miller L,Ruiz-Velasco V,Kellum JA

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:A cuffed tracheostomy tube facilitates prolonged mechanical ventilation and weaning but usually leads to prolonged voicelessness, which can be one of the most negative experiences of hospitalization. No randomized trials have examined the effects of targeted early communication intervention for the restorati...

journal_title：Critical care medicine

authors： Freeman-Sanderson AL,Togher L,Elkins MR,Phipps PR

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Endovascular treatment for acute ischemic stroke with a large vessel occlusion was recently shown to be effective. We aimed to develop a score capable of predicting large vessel occlusion eligible for endovascular treatment in the early hospital management. DESIGN:Retrospective, cohort study. SETTING:Two t...

journal_title：Critical care medicine

authors： Vanacker P,Heldner MR,Amiguet M,Faouzi M,Cras P,Ntaios G,Arnold M,Mattle HP,Gralla J,Fischer U,Michel P

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:To investigate family perceptions of having a nurse participating in family conferences and to assess the psychologic well being of the same families after ICU discharge. DESIGN:Mixed-method design with a qualitative study embedded in a single-center randomized study. SETTING:Twelve-bed medical-surgical IC...

journal_title：Critical care medicine

authors： Garrouste-Orgeas M,Max A,Lerin T,Grégoire C,Ruckly S,Kloeckner M,Brochon S,Pichot E,Simons C,El-Mhadri M,Bruel C,Philippart F,Fournier J,Tiercelet K,Timsit JF,Misset B

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Conflict is common between physicians and surrogate decision makers around end-of-life care in ICU. Involving experts in conflict management improve outcomes, but little is known about what differences in conflict management styles may explain the benefit. We used simulation to examine potential differences ...

journal_title：Critical care medicine

authors： Chiarchiaro J,White DB,Ernecoff NC,Buddadhumaruk P,Schuster RA,Arnold RM

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To compare the classification performance of the Revised Atlanta Classification, the Determinant-Based Classification, and a new modified Determinant-Based Classification according to observed mortality and morbidity. DESIGN:A prospective multicenter observational study conducted in 1-year period. SETTING:F...

journal_title：Critical care medicine

authors： Zubia-Olaskoaga F,Maraví-Poma E,Urreta-Barallobre I,Ramírez-Puerta MR,Mourelo-Fariña M,Marcos-Neira MP,Epidemiology of Acute Pancreatitis in Intensive Care Medicine Study Group.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:In acute respiratory distress syndrome, conservative fluid management increases ventilator-free days without affecting mortality. Response to fluid management may differ based on patients' initial central venous pressure. We hypothesized that initial central venous pressure would modify the effect of fluid m...

journal_title：Critical care medicine

authors： Semler MW,Wheeler AP,Thompson BT,Bernard GR,Wiedemann HP,Rice TW,National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network.

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:Our understanding of the acute respiratory distress syndrome in children is limited, and literature is dominated by investigations in adult patients. Recent preclinical studies suggest that the susceptibility to and severity of acute respiratory distress syndrome in children could differ from that in adults....

journal_title：Critical care medicine

authors： Schouten LR,Veltkamp F,Bos AP,van Woensel JB,Serpa Neto A,Schultz MJ,Wösten-van Asperen RM

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:The contribution of individual immune response to Staphylococcus aureus bacteremia on outcome has not been well studied. The objective was to relate the host cytokine response to outcome of Staphylococcus aureus bacteremia. DESIGN:Prospective observational study. SETTING:Three U.S. university-affiliated me...

journal_title：Critical care medicine

authors： Minejima E,Bensman J,She RC,Mack WJ,Tuan Tran M,Ny P,Lou M,Yamaki J,Nieberg P,Ho J,Wong-Beringer A

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Sympathetic vasoconstriction regulates peripheral circulation and controls blood pressure, but sepsis is associated with hypotension. We evaluated whether apparent loss of sympathetic vasoconstrictor responsiveness relates to distended smooth muscles or to endotoxemia and/or hypoxia. DESIGN:Prospective descr...

journal_title：Critical care medicine

authors： Brassard P,Zaar M,Thaning P,Secher NH,Rosenmeier JB

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the association between length of ICU stay and 1-year mortality for elderly patients who survived to hospital discharge in the United States. DESIGN:Retrospective cohort study of a random sample of Medicare beneficiaries who survived to hospital discharge, with 1- and 3-year follow-up, stratifie...

journal_title：Critical care medicine

authors： Moitra VK,Guerra C,Linde-Zwirble WT,Wunsch H

更新日期：2016-04-01 00:00:00

abstract：:The current definition of sepsis is life-threatening, acute organ dysfunction secondary to a dysregulated host response to infection. Criteria to operationalize this definition can be judged by six domains of usefulness (reliability, content, construct and criterion validity, measurement burden, and timeliness). The r...

journal_title：Critical care medicine

authors： Seymour CW,Coopersmith CM,Deutschman CS,Gesten F,Klompas M,Levy M,Martin GS,Osborn TM,Rhee C,Warren DK,Watson RS,Angus DC

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To describe a case of hepatic subcapsular hematoma causing an acute Budd-Chiari-like syndrome, leading to hepatic compartment syndrome, which combines compression of intrahepatic vessels on CT, acute liver failure, and refractory shock. DESIGN:Case report. SETTING:Surgical ICU of a university teaching hospi...

journal_title：Critical care medicine

authors： Marcaire F,Malavieille F,Pichot-Delahaye V,Floccard B,Rimmelé T

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:Palliative care is now recognized as an essential component of comprehensive care in serious illness that interferes with quality of life. We explored utilization of palliative care in spontaneous intracerebral hemorrhage at a population level using a large national database. DESIGN:Population based cross-s...

journal_title：Critical care medicine

authors： Murthy SB,Moradiya Y,Hanley DF,Ziai WC

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:To provide an overview of key elements of the Affordable Care Act. To evaluate ways in which the Affordable Care Act will likely impact the practice of critical care medicine. To describe strategies that may help health systems and providers effectively adapt to changes brought about by the Affordable Care A...

journal_title：Critical care medicine

authors： Dogra AP,Dorman T

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Leucine-rich repeat and immunoglobulin domain-containing protein (LINGO)-1 is expressed in neural stem cells, and its neutralization results in sustained neuronal immaturity. Thus, targeted inhibition of LINGO-1 via RNA interference may enhance transplanted neural stem cell survival and neuronal differentiati...

journal_title：Critical care medicine

authors： Chen N,Cen JS,Wang J,Qin G,Long L,Wang L,Wei F,Xiang Q,Deng DY,Wan Y

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (4...

journal_title：Critical care medicine

authors： Alogna A,Manninger M,Schwarzl M,Zirngast B,Steendijk P,Verderber J,Zweiker D,Maechler H,Pieske BM,Post H

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To compare the oxidative stress induced by IV iron infusion in critically ill patients and in healthy volunteers. DESIGN:Multicenter, interventional study. SETTING:Two ICUs and one clinical research center. SUBJECTS:Anemic critically ill patients treated with IV iron and healthy volunteers. INTERVENTIONS:...

journal_title：Critical care medicine

authors： Lasocki S,Piednoir P,Couffignal C,Rineau E,Dufour G,Lefebvre T,Puy H,Duval X,Driss F,Schilte C

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The equipment, monitor alarms, and acuity of patients in ICUs make it one of the loudest patient care areas in a hospital. Increased sound levels may contribute to worsened outcomes in these particularly vulnerable patients. Our objective was to determine whether ambient sound levels in surgical ICUs comply w...

journal_title：Critical care medicine

authors： Tainter CR,Levine AR,Quraishi SA,Butterly AD,Stahl DL,Eikermann M,Kaafarani HM,Lee J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that hyperbaric oxygen therapy ameliorates delayed cognitive impairment after acute carbon monoxide poisoning by promoting neurogenesis through upregulating the brain-derived neurotrophic factor in the hippocampus. DESIGN:Laboratory animal experiments. SETTING:University/Medical cente...

journal_title：Critical care medicine

authors： Liu WC,Yang SN,Wu CW,Chen LW,Chan JY

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Measurement of blood lactate concentration in the early management of sepsis is an important step in severity assessment. High blood lactate levels in the early phase of sepsis have classically been thought to be related to tissue hypoxia, but other factors could intervene. We hypothesized that the activatio...

journal_title：Critical care medicine

authors： Contenti J,Occelli C,Corraze H,Lemoël F,Levraut J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:We aim to describe current clinical practice, the past decade of experience and factors related to improved outcomes for pediatric patients receiving high-frequency oscillatory ventilation. We have also modeled predictive factors that could help stratify mortality risk and guide future high-frequency oscillat...

journal_title：Critical care medicine

authors： Rettig JS,Smallwood CD,Walsh BK,Rimensberger PC,Bachman TE,Bollen CW,Duval EL,Gebistorf F,Markhorst DG,Tinnevelt M,Todd M,Zurakowski D,Arnold JH

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To date, no study has systematically investigated the impact of drowning-induced asphyxia on hemostasis. Our objective was to test the hypothesis that asphyxia induces bleeding by hyperfibrinolytic disseminated intravascular coagulation. DESIGN:Observational study. SETTING:A 2,100-bed tertiary care facility...

journal_title：Critical care medicine

authors： Schwameis M,Schober A,Schörgenhofer C,Sperr WR,Schöchl H,Janata-Schwatczek K,Kürkciyan EI,Sterz F,Jilma B

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to determine whether selective inflammatory cytokine concentrations within cerebrospinal fluid are useful markers for the differential diagnosis of aseptic and bacterial meningitis within neurosurgical patients. DESIGN:Prospective, open-label, observational, cohort stud...

journal_title：Critical care medicine

authors： Liu ZH,Tu PH,Chen NY,Yip PK,Bowes AL,Lee CC,Chan SH,Kung CC,Wang AY,Wu CT,Lee ST

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Corticosteroid therapy is frequently used in septic patients given the rationale that there is an increased demand for corticosteroid in sepsis, and up to 60% of severe septic patients experience adrenal insufficiency. However, the efficacy of corticosteroid therapy and whether the therapy should be based on...

journal_title：Critical care medicine

authors： Ai J,Guo L,Zheng Z,Wang SX,Huang B,Li XA

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:With the exception of a few single-center descriptive reports, data on critical care organizations are relatively sparse. The objectives of our study were to determine the structure, governance, and experience to date of established critical care organizations in North American academic medical centers. DES...

journal_title：Critical care medicine

authors： Pastores SM,Halpern NA,Oropello JM,Kostelecky N,Kvetan V

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis. DESIGN:Prospective, observational clinical study with in vivo and ex vivo translational laboratory investigations. SETTING:General ICU and university research laboratory. SUBJECTS...

journal_title：Critical care medicine

authors： Alhamdi Y,Abrams ST,Cheng Z,Jing S,Su D,Liu Z,Lane S,Welters I,Wang G,Toh CH

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that intra-coronary transfusion of circulation-derived autologous CD34+ cells can improve ischemia-related left ventricular dysfunction in patients with severe diffuse coronary artery disease refractory to medication and unsuitable for coronary intervention. DESIGN:A prospect...

journal_title：Critical care medicine

authors： Lee FY,Chen YL,Sung PH,Ma MC,Pei SN,Wu CJ,Yang CH,Fu M,Ko SF,Leu S,Yip HK

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Subarachnoid hemorrhage results in significant long-lasting neurologic sequelae. Here, we investigated whether human albumin improves long-term outcomes in experimental subarachnoid hemorrhage and whether neurovascular remodeling is involved in the protection of albumin. DESIGN:Laboratory investigation. SET...

journal_title：Critical care medicine

authors： Xie Y,Liu W,Zhang X,Wang L,Xu L,Xiong Y,Yang L,Sang H,Ye R,Liu X

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:Severe sepsis poses a major burden on the U.S. healthcare system. Previous epidemiologic studies have not differentiated community-acquired severe sepsis from healthcare-associated severe sepsis or hospital-acquired severe sepsis hospitalizations. We sought to compare and contrast community-acquired severe s...

journal_title：Critical care medicine

authors： Page DB,Donnelly JP,Wang HE

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The association between cigarette smoke exposure and the acute respiratory distress syndrome in patients with the most common acute respiratory distress syndrome risk factors of sepsis, pneumonia, and aspiration has not been well studied. The goal of this study was to test the association between biomarker-co...

journal_title：Critical care medicine

authors： Calfee CS,Matthay MA,Kangelaris KN,Siew ED,Janz DR,Bernard GR,May AK,Jacob P,Havel C,Benowitz NL,Ware LB

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To examine the ways in which healthcare professionals work together in the ICU setting, through a consideration of the contextual, organizational, processual, and relational factors that impact their interprofessional collaboration. DESIGN:Data from over 350 hours of ethnographic observation and 35 semistruc...

journal_title：Critical care medicine

authors： Alexanian JA,Kitto S,Rak KJ,Reeves S

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Preliminary experimental data suggest that selective β1-blockers may improve ex vivo cardiac function in animal sepsis. Currently, the effects of esmolol on in vivo cardiac function and on vascular function are unknown. The present study was designed to examine the effects of the β1-selective blocker esmolol ...

journal_title：Critical care medicine

authors： Kimmoun A,Louis H,Al Kattani N,Delemazure J,Dessales N,Wei C,Marie PY,Issa K,Levy B

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Over 2,500 children undergo hematopoietic stem cell transplantation in the United States each year, and up to 35% require PICU support for life-threatening complications. PICU mortality has dropped from 85% to 44%, but interpretation is confounded by significant cohort heterogeneity. Reports conflict regardi...

journal_title：Critical care medicine

authors： Zinter MS,Dvorak CC,Spicer A,Cowan MJ,Sapru A

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Centers for Disease Control and Prevention built up new surveillance paradigms for the patients on mechanical ventilation and the ventilator-associated events, comprising ventilator-associated conditions and infection-related ventilator-associated complications. We assess 1) the current epidemiology of venti...

journal_title：Critical care medicine

authors： Bouadma L,Sonneville R,Garrouste-Orgeas M,Darmon M,Souweine B,Voiriot G,Kallel H,Schwebel C,Goldgran-Toledano D,Dumenil AS,Argaud L,Ruckly S,Jamali S,Planquette B,Adrie C,Lucet JC,Azoulay E,Timsit JF,OUTCOMEREA Study

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To assess the impact of sepsis classification and multidrug-resistance status on outcome in patients receiving appropriate initial antibiotic therapy. DESIGN:A retrospective cohort study. SETTING:Barnes-Jewish Hospital, a 1,250-bed teaching hospital. PATIENTS:Individuals with Enterobacteriaceae sepsis, sev...

journal_title：Critical care medicine

authors： Burnham JP,Lane MA,Kollef MH

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Although highly active antiretroviral therapy has led to improved survival in HIV-infected individuals, outcomes for HIV-infected patients with sepsis in the post-highly active antiretroviral therapy era are conflicting. Access to highly active antiretroviral therapy and healthcare disparities continue to af...

journal_title：Critical care medicine

authors： Cribbs SK,Tse C,Andrews J,Shenvi N,Martin GS

更新日期：2015-08-01 00:00:00